The Medical Advisor

Medically reviewed and updated for 2026 — By the OneDayMD Editorial Team Quick Answer The anti-aging supplements with the strongest human evidence are vitamin D3 (with K2 and magnesium), omega-3 fatty acids, creatine, glycine, and collagen peptides — each backed by large randomized trials tied to biological aging, mortality, or a specific hallmark of aging. Urolithin A, NAC/GlyNAC, and spermidine have promising but smaller human trial support. NMN, resveratrol, and CoQ10 are well-studied for safety and biomarkers but have not yet shown they extend human lifespan. A 2025 NIH-led study also overturned the idea that low taurine drives aging in humans — see Section 4. No supplement replaces diet, exercise, sleep, and a doctor's guidance. Can supplements reverse your age? Can you supplement your way out of aging? We dug into more than 1,000 research studies — including several major 2025 and 2026 trials — to find out. Generic AI chatbot answers about longevity supp...

Can natural supplements effectively treat or prevent dementia? Some studies suggest that B vitamins, omega-3 fatty acids, vitamin D3 and magnesium may have modest benefits, but it's important to consult a doctor before starting any supplement regimen. Let's dive into the evidence. Contents Introduction Best Supplements to Prevent and Reverse Alzheimer's and Dementia Vitamin D3 B Vitamins Omega-3 fatty acids Magnesium and Molecular Hydrogen Ginko Biloba Soy Isoflavones Ginseng Melatonin Green Tea (EGCG) Creatine Quercetin Coconut Oil Lutein (carotenoids) Selenium Zinc Citicoline TMG and Betaine Combined Metabolic Activators (NR, NAC, L-Carnitine and L-Serine) Prebiotics and Probiotics Centrum Silver Multivitamin NAC (N-Acetyl Cysteine) Choline ...