The Medical Advisor

Cancer treatment has transformed dramatically over the past decade. From chemotherapy and radiation to targeted therapies, each advance has sought to tip the balance in favor of the patient. Now, cell-based immunotherapies — therapies that harness and engineer the body’s immune system to fight cancer — are taking center stage. Two of the most promising approaches are CAR-T and CAR-NK cell therapies. But what makes them different, and how are emerging innovations, including AI and NK cell expansion, shaping the future of immunotherapy? Understanding CAR-T Therapy CAR-T (Chimeric Antigen Receptor T-cell) therapy involves harvesting a patient’s T cells, genetically engineering them to recognize specific cancer antigens, and reinfusing them into the body. These modified T cells can detect and destroy cancer cells with remarkable precision. Strengths of CAR-T: High efficacy in blood cancers: Durable remissions have been reported in leukemia and lymphoma patients. Long-term immune memory: ...

Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, ALS, and vascular dementia represent one of modern medicine’s greatest unmet challenges. Despite decades of research and billions of dollars invested, disease-modifying therapies remain limited, expensive, and often marginal in benefit. This has driven growing interest in repurposed drugs —existing medications originally developed for other conditions that may influence neurodegeneration through mitochondrial, metabolic, inflammatory, or protein-aggregation pathways. Some repurposed candidates show promise. Many fail. A few persist in a gray zone between compelling biology and inconclusive clinical evidence. This pillar page provides a clear, evidence-based framework for understanding repurposed neurodegenerative therapies—what they target, how strong the evidence is, and how to separate legitimate research from hype. What Are Repurposed Neurodegenerative Therapies? Drug repurposing (also called drug repositio...

Introduction Cancer metabolism has emerged as a promising area of research, with growing interest in therapies that target cellular energy pathways, inflammation, and metabolic vulnerabilities. Beyond conventional surgery, chemotherapy, radiation, and immunotherapy, a range of metabolic interventions—dietary approaches, repurposed drugs, supplements, and lifestyle modifications—are being investigated for their potential to support cancer control or enhance treatment response. While mainstream oncology guidelines (ASCO, NCCN, ESMO) prioritize interventions supported by high-quality randomized controlled trials (RCTs) and meta-analyses, many metabolic interventions rely on mechanistic plausibility, preclinical studies, observational data, or small case series. This article evaluates these emerging strategies, emphasizing evidence strength and translational potential rather than definitive therapeutic claims. Diverse cancer hallmarks targeted by repurposed non-oncology drugs. This figure ...

Summary  The video script discusses the importance of maintaining heart health and how to lower blood pressure. It covers topics such as the role of the heart, blood, cholesterol, and blood vessels in heart health. It also addresses the myths surrounding cholesterol, salt, and blood thinners. The script emphasizes the significance of exercise, nutrition, stress management, and proper breathing techniques in maintaining a healthy heart. Highlights 🩺 The script challenges the myth that cholesterol causes heart disease, citing multiple sources and experts. 💊 It highlights the potential dangers and side effects of cholesterol-lowering medication, such as memory loss and increased risk of dementia. 🧂 The script dispels the misconception that salt is universally harmful and discusses the importance of using natural, minimally processed salts. 🏋️ The script emphasizes the role of exercise in strengthening the heart and improving overall heart health. 🌬️ It explains the significa...

Is high blood pressure a silent killer — or a misunderstood metric driving overtreatment? The truth lies in between. High blood pressure has long been framed as a universal villain: a condition that must be aggressively lowered, often for life, to prevent heart attacks, strokes, and early death. Yet critics argue that hypertension has become overdiagnosed, overtreated, and detached from its biological context (1). So which is it — lifesaving intervention or medical overreach? The answer is more complex than either side admits. This article critically examines the modern blood pressure paradigm: where it is evidence-based, where it falls short, and how patients can navigate care without falling into either blind compliance or blanket rejection. How Hypertension Became a Medical Absolute Blood pressure is easy to measure, inexpensive to monitor, and strongly correlated with cardiovascular risk at a population level. That combination made it an ideal screening metric — and eventually, a t...

Introduction Linoleic acid (LA) is the most abundant omega‑6 polyunsaturated fatty acid (PUFA) in modern diets. It is found primarily in seed and vegetable oils such as soybean, corn, sunflower, safflower, and canola oil, as well as in nuts, seeds, and some animal foods. Because industrial food production dramatically increased omega‑6 intake over the past century, linoleic acid has become a focal point of controversy. Some commentators claim it drives inflammation, obesity, metabolic disease, mitochondrial damage, cancer, and cardiovascular disease. This article reviews the best available human evidence, separates mechanistic speculation from clinical reality, and explains how linoleic acid actually fits into a healthy diet. What Is Linoleic Acid? Linoleic acid is an essential fatty acid , meaning the human body cannot synthesize it. It is required for: Cell membrane structure and fluidity Skin barrier function Normal immune signaling Production of longer‑chain fatty acids Deficiency ...

Introduction Repurposing existing drugs for oncology offers a promising pathway to identify affordable, globally accessible therapies for advanced cancer. These agents may modulate metabolism, inflammation, or cellular stress pathways relevant to tumor growth. However, mainstream oncology guidelines (ASCO, NCCN, ESMO) recommend interventions only when supported by robust clinical evidence , typically from randomized controlled trials (RCTs) or well-designed prospective studies. Mechanistic plausibility, in vitro studies, or anecdotal cases alone do not constitute sufficient evidence to guide treatment. This article reviews 19 repurposed drugs highlighted in the OneDayMD AI ranking , situating each within an evidence-aware framework , and clarifies the distinction between AI-generated prioritization and clinical validation. Diverse cancer hallmarks targeted by repurposed non-oncology drugs. This figure was created with Biorender.com. Source:  Nature 2024 Evidence Tier Framework To...