The Medical Advisor

Medically Reviewed by: Dr. Frank Yap, MD | Written by: OneDayMD Editorial Team | Published: March 2026 | Last updated: October 2026 Quick Answer Semaglutide (“sema”), tirzepatide (“tirz”), and retatrutide (“reta”) represent three stages in the evolution of incretin-based weight-loss medications: a single GLP-1 receptor agonist, a dual GIP/GLP-1 receptor agonist, and an investigational triple GIP/GLP-1/glucagon receptor agonist, respectively. Semaglutide is an FDA-approved GLP-1 receptor agonist that has demonstrated average weight loss of approximately 15% in clinical trials, with some individuals losing more. Tirzepatide, a dual GIP/GLP-1 receptor agonist, has demonstrated average weight loss of up to approximately 21–22% in trials. Retatrutide, an investigational triple agonist targeting GIP, GLP-1, and glucagon receptors, has shown promising weight-loss results in clinical trials but is not yet FDA-approved. What changed in this update (Oct 2026): replaced pre-Phase-3 esti...

Home › GLP-1 Hub By Dr. Frank Yap, MD | One Day Media Network | Published October 13, 2026 | Last updated: October 13, 2026 | Purpose: evidence and safety education, not individual medical advice Quick Answer As of October 2026, the FDA has approved two GLP-1 weight-loss pills, oral Wegovy (semaglutide 25 mg, December 2025) and Foundayo (orforglipron, April 1, 2026), alongside weekly injections such as Wegovy, Zepbound, Ozempic and Mounjaro. Retatrutide and CagriSema are not approved in the US. Compounded and gray-market GLP-1 products are not FDA-approved. Use a licensed prescriber and a regulated pharmacy. On this page Which GLP-1 medicines are approved in October 2026? Are GLP-1 pills as effective as injections? Retatrutide and CagriSema: what is known so far? Safety and side effects: what should patients know? Compounded, gray-market and research peptides: what are the risks? How strong is the evidence? (CEBM grades) Where to start: the complete GLP-1 evidence library Using...