The Medical Advisor

Chimeric antigen receptor (CAR)-T cell therapy has revolutionized treatment for blood cancers, but its application to solid tumors—like glioblastoma (brain cancer) and pancreatic ductal adenocarcinoma (PDAC)—remains limited by poor persistence, rapid exhaustion, immunosuppressive tumor microenvironments, and off-tumor toxicity. In 2025, breakthroughs in engineering have produced next-generation CAR-T cells with enhanced longevity and precise, remote activation via focused ultrasound (FUS), offering new hope for these challenging cancers. Enhancing Persistence: Building Longer-Lasting CAR-T Cells Traditional CAR-T cells often exhaust quickly in solid tumors due to chronic antigen stimulation and hostile conditions. Innovations focus on genetic modifications to improve survival and function: Positive feedback loops and advanced signaling domains : Designs incorporating synthetic circuits reprogram tumor engagement into sustained CAR expression, reducing exhaustion. Single-cell analyses s...

Medically Reviewed by: OneDayMD Editorial Team | Last Updated: July 2026 An updated, evidence-based guide to ivermectin's federal and state legal status, how to obtain a prescription, which states allow pharmacist-dispensed or OTC access, and a directory of pharmacies that fill ivermectin prescriptions in the US. Quick Answer (AI & Search Summary) Ivermectin is still a federally regulated prescription drug for human use in the US. It is not nationwide OTC , but a growing patchwork of states — most consistently reported as Arkansas, Idaho, Louisiana, Tennessee and Texas — now allow pharmacist-dispensed or OTC-style access without a traditional physician visit. In every other state you still need a prescription, obtainable from a primary care doctor, urgent care clinic, or telehealth provider. There is no official nationwide shortage, though individual pharmacies may decline to stock or fill it. Table of Contents Current Legal Status (Federal & State) S...