The Medical Advisor

Breast cancer remains one of the most challenging and prevalent malignancies worldwide, with metastatic and treatment-resistant cases posing significant therapeutic hurdles. Conventional treatment options, including chemotherapy, targeted therapies, and immunotherapy, often reach their limits, particularly in advanced stages such as triple-negative breast cancer (TNBC).  For patients with actionable mutations identified through molecular profiling, targeted therapies are the preferred treatment approach. In particular, for estrogen receptor–positive (ER+) breast cancer patients with a low Oncotype DX recurrence score, hormonal therapy alone is often appropriate, as genomic testing indicates a low risk of cancer recurrence and supports de-escalation of more aggressive systemic treatments. The preference for targeted treatments reflects their demonstrated efficacy in improving outcomes in these molecularly defined subgroups, underscoring the importance of comprehensive genomic profil...