The Medical Advisor

Medically Reviewed by: Dr Frank Yap, MD | Written by: OneDayMD Editorial Team | Last Updated: August 2026 Quick Answer:  Cancer treatment is moving from a one-size-fits-all model toward increasingly biomarker-driven, immune-based, targeted and combination therapy . The most consequential 2026 cancer breakthrough is daraxonrasib , an oral RAS(ON) inhibitor that nearly doubled overall survival in previously treated metastatic pancreatic cancer in the phase 3 RASolute 302 trial presented at ASCO 2026. Other major advances include the OPTIMA trial , showing many high-risk breast cancer patients can safely skip chemotherapy after genomic testing; the bispecific antibody ivonescimab , which outperformed standard immunotherapy in squamous lung cancer; continued expansion of CAR-T and cell therapies into solid tumors; and growing, evidence-tiered interest in repurposed drugs and metabolic approaches as complementary strategies. AACR 2026 and ASCO 2026 both emphasized that progress ...

The common denominator for overall health—including longevity, brain health, gut health, liver health, immune health, and kidney health—is mitochondrial health. Many chronic diseases can be traced to mitochondrial dysfunction. Seemingly diverse conditions—including  diabetes ,  hypertension ,  heart disease ,  cancer , allergies, autoimmune diseases such as rheumatoid arthritis, and even various mental illnesses—can be understood through a “unified theory” of mitochondrial imbalance. Mitochondria are involved in many vital processes in human cells, including energy production, fatty-acid oxidation, and the Tricarboxylic Acid (TCA) cycle, calcium signaling, apoptosis (cellular death), and heat production. However to simplify things let’s talk about energy and longevity which is what their function translates to for practical purposes. And to help this occur, we can review the health practices, along with the best supplements to improve mitocho...