The Medical Advisor

Dimethyl sulfoxide (DMSO), a solvent discovered in the 19th century and explored medically since the 1960s, has garnered attention for its potential in ophthalmology despite FDA restrictions halting much U.S. research. Initially praised for treating diverse conditions, it faced suppression, yet persists in alternative medicine, veterinary applications, and self-experiments for issues like cataracts, macular degeneration, floaters, glaucoma, dry eyes, infections, and retinal diseases. Combined with castor oil, it offers synergistic benefits for hydration and inflammation reduction, supported by anecdotal reports. (1, 2, 7) While not mainstream, its resurgence through online communities highlights non-invasive alternatives to surgery or injections. Mechanisms of Action DMSO penetrates tissues rapidly, reducing inflammation, improving microcirculation, and reviving dormant cells by stabilizing proteins and dissolving aggre...

Introduction Cancers of the female reproductive system, including ovarian, endometrial (uterine), and cervical cancers, represent a significant global health burden, often presenting at advanced stages with limited treatment options and poor prognosis. Conventional therapies such as chemotherapy, radiation, and surgery, while effective in some cases, frequently fail in recurrent or metastatic disease, prompting exploration of drug repurposing strategies.  This compilation examines emerging case reports on the off-label use of antiparasitic agents—primarily ivermectin and fenbendazole, alongside related benzimidazoles like mebendazole—in managing these malignancies. Drawing from 19 documented cases, the article categorizes outcomes by cancer type and integrates mechanistic insights from preclinical studies, where these compounds have demonstrated antitumor effects such as microtubule disruption, inhibition of oncogenic signaling pathways (e.g., PAK1, Wnt/β-catenin), induction of apo...