DMSO: What It Actually Does, What the Evidence Shows, and How to Use It Safely (2026)
OneDayMD Evidence Guide • Updated October 2026 Dimethyl sulfoxide (DMSO) is an unusual compound: a powerful solvent, a membrane-penetration enhancer and a substance with genuine clinical applications. It is also surrounded by exaggerated claims. This guide separates established medicine from promising research, anecdotes and unsupported “miracle cure” narratives. Evidence focus: topical DMSO, interstitial cystitis, pain, penetration enhancement, safety, drug interactions, cancer research, amyloidosis and common online claims. Important: The fact that DMSO penetrates biological membranes does not mean it makes any substance placed on the skin safe or effective. Because DMSO can enhance penetration, contaminated skin or inappropriate mixtures may increase exposure to other chemicals or drugs. What Is DMSO? Dimethyl sulfoxide (DMSO) is a sulfur-containing organic compound with the chemical formula C 2 H 6 OS. It is a clear liquid that mixes readily with water...