The Medical Advisor

Constipation affects millions worldwide, characterized by infrequent bowel movements, hard stools, or difficulty passing them. While lifestyle changes form the foundation of relief, prebiotic fibers like inulin—found naturally in foods such as onions, garlic, leeks, and Jerusalem artichokes—have gained attention for their potential to support gut health and regularity. Recent research also explores inulin's role in protecting against fatty liver disease, alongside emerging cautions about high-dose supplemental forms. Common inulin-rich foods: onions, garlic, leeks, and chicory root. Proven Natural Remedies for Constipation Relief Evidence-based approaches emphasize gradual changes to avoid bloating or discomfort: Stay Hydrated : Dehydration hardens stool. Aim for clear or pale yellow urine as a hydration marker, typically requiring 8–10 glasses of water daily. Adequate water intake is essential for softening stool and preventing constipation. Increase Fiber Intake Gradually : Targe...

Abstract Butyrate, a short-chain fatty acid (SCFA) produced via bacterial fermentation of dietary fiber in the colon, has emerged as a critical modulator of gut health, immune regulation, and neurocognitive function. This review explores the metabolic, immunological, and neurological roles of butyrate, examining its mechanisms of action and implications for chronic disease prevention. Current evidence underscores the necessity of dietary and lifestyle interventions to enhance butyrate production and optimize overall health outcomes. Introduction Butyrate, one of the principal SCFAs generated by gut microbiota, plays a fundamental role in maintaining colonic homeostasis, regulating immune responses, and supporting neural function. Recent studies have emphasized its influence on metabolic pathways, immune modulation, and the gut-brain axis. Understanding butyrate’s diverse physiological roles is essential for advancing therapeutic strategies targeting gut dysbiosis, inflammatory disorder...

Lung cancer remains one of the most challenging and deadly malignancies worldwide, with limited effective treatment options for advanced stages despite advances in targeted therapies and immunotherapies. Patients with metastatic or treatment-resistant disease often face poor prognoses and unmet clinical needs, prompting exploration of novel and adjunctive therapeutic approaches. For patients with actionable mutations identified through molecular profiling, targeted therapies are the preferred treatment approach. In particular, for "PD-L1 High Non-Small Cell Lung Cancer", single-agent immunotherapy may be more effective and better tolerated than chemotherapy in selected patients. The preference for targeted treatments reflects their demonstrated efficacy in improving outcomes in these molecularly defined subgroups, underscoring the importance of comprehensive genomic profiling in guiding personalized therapy decisions. However, targeted agents are only applicable to small pati...