The Medical Advisor

Dimethyl sulfoxide (DMSO), a solvent discovered in the 19th century and explored medically since the 1960s, has garnered attention for its potential in ophthalmology despite FDA restrictions halting much U.S. research. Initially praised for treating diverse conditions, it faced suppression, yet persists in alternative medicine, veterinary applications, and self-experiments for issues like cataracts, macular degeneration, floaters, glaucoma, dry eyes, infections, and retinal diseases. Combined with castor oil, it offers synergistic benefits for hydration and inflammation reduction, supported by anecdotal reports. (1, 2, 7) While not mainstream, its resurgence through online communities highlights non-invasive alternatives to surgery or injections. Mechanisms of Action DMSO penetrates tissues rapidly, reducing inflammation, improving microcirculation, and reviving dormant cells by stabilizing proteins and dissolving aggre...

Abstract Cancer remains a leading cause of global mortality, increasingly recognized as a metabolic disorder characterized by dysregulated energy pathways such as aerobic glycolysis (Warburg effect) and dependency on fermentable substrates like glucose and glutamine. Traditional therapies, while effective, often exacerbate mitochondrial dysfunction and foster resistance. This review synthesizes recent evidence on metabolic interventions and repurposed drugs targeting cancer stem cells (CSCs), restoring oxidative phosphorylation (OxPhos), and modulating the tumor microenvironment (TME). Drawing from over 1,000 peer-reviewed studies, including meta-analyses, randomized controlled trials (RCTs), case series, and preclinical data, we prioritize human evidence to outline core principles, a curated top 10 interventions ranked by CSC targeting, metabolic disruption, clinical efficacy, and safety, integrated protocols, and future directions. Emphasis is placed o...